Senior In Vitro Scientist, Translational Hepatic Safety (R-149040) Gothenburg, Sweden
Senior In Vitro Scientist, Translational Hepatic Safety
Location: Gothenburg Sweden
Do you want to develop your lab-based curiosity about new preclinical hepatic safety techniques, influence key projects and progress into management with a world-leading pharmaceutical company? Here is your opportunity at AstraZeneca, we are seeking Senior Scientists within Translational Hepatic Safety to join us at AZ Gothenburg in Sweden, where research-led ideas are turned into new medicines that make a real difference in healthcare.
Main duties and responsibilities
- Design and deliver in vitro experimental data to support projects across the portfolio and in line with the liver organ strategy and mechanistic problem solving needed to de-risk projects
- Develop and deliver expertise in drug metabolism, biomarkers, 3D model technology with respect to the liver organ strategy
- Scientific leadership to use in depth hepatic toxicological expertise to develop and implement scientific methodology for projects, or provide specialist technical input and problem solving into toxicology issues with projects
- Evaluation and validation of the translatability of novel physiological hepatic models
- Use technical expertise and apply knowledge to lead groundbreaking projects in order to exploit new technologies and influence their adoption within AstraZeneca
- Sharing experience, knowledge and industry developments with peer scientists
- Responsible for supervision of students if required
- Interaction with staff on all levels and from all fields and areas, e.g. toxicologists, pathologists, DMPK scientists and project teams
Essential requirements
- A PhD level education (alternatively equivalent training experience) in Toxicology, Pharmacology, Biomedical Science or related field
- Significant experience in a relevant scientific field
- Extensive experience in the area of liver biology, hepatic injury, drug metabolism
- Extensive training in cell culture, sterile work and 3D culture e.g. spheroids
- Expertise in either novel in vitro hepatic models, hepatic biomarkers, BSep / bile acid transport, reactive metabolites, cholestasis, mitochondrial toxicity or related mechanism of hepatic toxicity providing specialised competence in that area
- An ability to think and act creatively both independently, and within teamworks
- Highly motivated, innovative scientist with the ability to influence and with a team-oriented approach
- Excellent English language skills, both spoken and in writing
Desirable requirements
- A detailed understanding of drug metabolism, pharmacokinetics
- Knowledge of lab automation tools for making in vitro work more efficient
- Scientific experience in liver disease area including NAFLD, NASH, etc.
- Theoretical knowledge and long term experience of relevant techniques and technologies
- Well founded understanding of AstraZeneca's business objectives that are related to R&D
Why AstraZeneca?
Join a place built on innovation and creativity. Where different views and perspectives are welcomed and valued. Be part of a dedicated Research & Development team. Fuelled by our commitment to help more patients, strengthen our pipeline and grow our area.
So, what’s next? If this sounds like a challenge for you – apply today!
We look forward to get to know you better. Send in your application as soon as possible, but no later than 19th of October.