Industrial PhD position in PET chemistry (R-072356) Gothenburg, Sweden
We are now looking to fill an industrial PhD position in synthetic chemistry within a Marie Skłodowska-Curie Innovative Training Network
AstraZeneca and the Aarhus University will offer the PhD student a unique opportunity to gain world class knowledge and hands-on experience in various applications of medicinal chemistry and drug discovery at the forefront of biomedical research and development. The successful candidate will also participate in the network’s training activities and work placements at the laboratories of the Aarhus University, Denmark and ICIQ, Spain. The degree will be awarded by the Aarhus University.
Projects:
The doctoral training positions advertised herein are to be filled at AstraZeneca R&D Gothenburg, Sweden in conjunction with the Aarhus University, Denmark (where the successful candidates will be registered for a PhD).
The research project will focus on the Development of late-stage and rapid carboxylation techniques with 14CO2 in drug development programs. The objectives of the project are:
Investigate the application of alkyl halides and pseudohalides for the synthesis of alkyl–Ni complexes and their ability to undergo rapid carboxylations with 14CO2 in the presence of a reductant Adapt new electrochemical and photolytic methods for the transformation of alkyl silicates to corresponding carboxylates with 14CO2 applying Ni-complexes Apply the developed conditions for late stage 14C labelling of pharmaceutically relevant alkyl carboxylates
The expected results are:
New techniques for late-stage carbon-14 isotope labelling adaptable to drug development programs A detailed understanding of the steps involved in transition metal-mediated carboxylations, particularly with nickel. Fast carboxylation reactions with easy-to-prepare intermediates
Tasks include:
The successful candidates will work together with 14 other PhD students within the Co2perate Consortium and will be included in a network-wide training and secondment programme. Travel for up to 6 months will be required.
Qualifications:
- A master’s degree in chemistry, medicinal chemistry, or chemical biology or the equivalent, preferably with a research project in organic synthesis. The applicant cannot possess a PhD or MD degree
- At the time of recruitment be in their first 4 years of research career.
- An excellent track record from previous studies, along with experience in organic synthesis or medicinal chemistry.
- Fluent in the English language (spoken and written/proficiency level).
About AstraZeneca:
AstraZeneca is a global, innovation-driven biopharmaceutical business that focuses on the discovery, development and commercialization of prescription medicines for some of the world’s most serious diseases. We're more than one of the world's leading pharmaceutical companies. At AstraZeneca, we're proud to have a unique workplace culture that inspires innovation and collaboration. Here, employees are empowered to express diverse perspectives - and are made to feel valued, energized and rewarded for their ideas and creativity.
Our Gothenburg site: https://www.astrazeneca.com/our-science/gothenburg.html
Life in Gothenburg: https://www.movetogothenburg.com/
Culture and atmosphere of the Gothenburg site: https://www.linkedin.com/feed/update/urn:li:activity:6496327311678410752/
Other:
In accordance with the Marie Skłodowska-Curie actions mobility requirements, candidates are only eligible for this position when they have spent no more than 12 months of their main activity (work, study) during the last three years in Sweden.
Contact person: Charles S. Elmore (+46 (0) 722 135 480)
Welcome with your application no later than February 23, 2020