Senior Research Associate, New Discovery and Platforms

W2 Contract-to-Hire

Salary Range: $93,600 - $114,400 per year

Location: Redwood City, CA - Onsite Role

Job Summary:

We are looking for an experienced Research Associate/Senior Research Associate to help the Discovery Sciences team accelerate our search for new oncology therapeutics. The successful candidate will join a high-performing team of experts in the use of cell-based screening techniques to drive the efficient identification and rapid development of clinically impactful drugs against frontier targets in oncology. They will contribute to our research portfolio from the bench by taking responsibility for analyzing, validating, and troubleshooting cellular assays and phenotypic screens.

Duties and Responsibilities:

• Extensive experience in culturing mammalian cells with sterile technique.
• Proficient in the design, development, and execution of microplate-based cellular assays suitable for the discovery, validation, and mechanistic characterization of fragment and small molecule modulators of oncology protein targets.
• Conversant in the selection and deployment of appropriate assay readouts like nanoBRET, alphaLISA, MSD, and CellTiterGlo.
• Experience with processing and delivering robust data in a timely fashion to research discovery teams is critical.
• Design and execution of lead discovery and phenotypic screening methods and experiments to identify compound hits and advance them through hit-to-lead and lead optimization stages
• Collaborate within Discovery Science and cross-functionally with Compound Management, Structural Biology, and Biology/Chemistry teams to develop and implement cell-based assays for hit identification and lead optimization, evaluating compound potency, selectivity, and mechanism of action.
• Develop, characterize, and execute novel assays to support screening and preclinical development.
• Communicate scientific progress effectively to the Discovery Sciences team and facilitate project execution within established timelines.
• Maintain detailed electronic lab notebook entries, draft protocols for experiments, assay data summaries, and manage reagent stocks.

Requirements and Qualifications:

• Bachelor’s degree with 2-5 years of experience or Master’s degree with 0-3 years of experience in biology, biochemistry, chemical biology, or related field
• Experience with cell-based assay development, validation, and troubleshooting
• Experience with RNA and DNA transfection protocols
• Familiarity with data processing and visualization tools for data analysis and figure generation (e.g., R, Vortex, GraphPad Prism, Genedata Screener, etc).
• Attention to detail with excellent organizational, experimental data recording, and time management skills
• Excellent written and verbal communication skills
• Innovative and flexible team player with high energy and a demonstrated willingness to learn in a fast-paced environment

Preferred Qualifications:

• Familiarity with automated liquid handling (SPT Dragonfly and/or Mosquito, Agilent Bravo, Tecan)
• Experience with high-throughput phenotypic screening
• Familiarity with transcriptomics or high content imaging techniques
• Facile with instrumentation, able to troubleshoot problems and work with engineers to generate successful solutions to technical limitations.
• Rigorous, quantitative, detail-oriented experimentalist with an understanding of statistics.

Bayside Solutions, Inc. is not able to sponsor any candidates at this time. Additionally, candidates for this position must qualify as a W2 candidate. 

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