Principal Scientist or Director

Direct Hire Full-Time Role

Salary Range: $120,000 - $140,000 per year

Location: Irvine, CA - Onsite Role

Job Summary:

We are seeking a highly motivated, passionate, and detail-oriented Principal Scientist to join our Antibody Therapeutics team. This is an exciting opportunity to contribute to a fast-growing, AI-driven biotherapeutics company dedicated to rapidly generating next-generation biologics for Immunology & Inflammation (I&I) and metabolic diseases.

Duties and Responsibilities:

• Lead the design, discovery, and optimization of monoclonal, bispecific, and multispecific antibodies using display and screening platforms (B-cell cloning, phage, and yeast display).
• Perform high-throughput antibody screening assays, including binding kinetics, ligand blocking, and epitope binning, to rapidly identify and prioritize lead candidates.
• Design and develop recombinant protein-based immunoassays to characterize therapeutic antibodies using biochemical and biophysical methods.
• Execute small- and large-scale antibody expression and purification using chromatography techniques and evaluate purity via SDS-PAGE, analytical SEC, and Western blot.
• Co-lead biotherapeutic discovery campaigns and partner closely with in vitro and in vivo pharmacology teams to evaluate PK/PD, efficacy, and safety profiles.
• Provide strategic and technical input on antibody design, developability, and candidate selection during early-stage development.
• Interface with CROs and external collaborators to ensure high-quality data generation and timely project execution.
• Present experimental results and program updates to project teams, senior management, and collaborators.
• Maintain accurate experimental documentation in ELN and ensure compliance with best data practices.
• Stay current with emerging literature and technologies relevant to antibody engineering and biologics discovery.

Requirements and Qualifications:

• PhD in Biochemistry, Biomedical Engineering, Molecular Biology, Immunology, or related discipline with at least 7 years (Principal Scientist) or 10 years (Director) of research experience working in a biotech or large pharma setting is a must.
• Experience with antibody pipeline discovery, screening, antibody engineering, and optimization in the field of I&I or metabolic diseases is a must.
• Expertise in designing and conducting in vitro protein-based assays using diverse biophysical and bioanalytical methods (e.g., SPR/BLI, ELISA, DLS, thermal stability, immunoassays) is a must.
• A strong understanding of protein engineering, Fc modifications, and developability assessments is essential.
• Ability to work independently and as part of a team in a fast-paced environment, with strong analytical and problem-solving skills, and attention to detail is essential.
• Experience with antibody screening databases and proficiency in data analysis/visualization software, such as Spotfire, Dotmatics, D360, etc., is a plus.
• Demonstrated scientific innovation and productivity, as evidenced by patents and/or peer-reviewed publications.
• Strong communication and interpersonal skills, with the ability to present complex data clearly to cross-functional teams, leadership, and collaborators.
• Self-motivated, collaborative, and enthusiastic about contributing to a multidisciplinary, early-stage biotech focused on breakthrough antibody therapeutics.

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