Scientist/Senior Scientist, Analytical Chemistry

Direct Hire Full-Time Role

Salary Range: $150,000 - $175,000 per year

Location: South San Francisco, CA - Onsite Role

Job Summary:

The candidate will contribute to the characterization of proteins, peptides, and conjugates, including any changes after exposure to biological matrices. The candidate will work in a highly collaborative team with the conjugation and functional assays teams, as well as senior leadership, to ensure data integration across functional areas for rapid decision-making and product iteration cycle time.  This position is expected to be on-site at our SSF facility. 

Requirements and Qualifications:

• PhD in analytical chemistry, biochemistry, or related scientific field and 3+ years of industry experience in the characterization of biologics, biologic conjugates, or peptides is required OR
• BS/MS in analytical chemistry, biochemistry, or related scientific field and 5+ years of industry experience in the characterization of biologics, biologic conjugates or peptides is required.
• Requires a background in liquid chromatography assays such as RP-HPLC, SEC, CEX, and HIC.  
• Develop and run analytical methods (LCMS, capillary electrophoresis, SDS-PAGE, and high-throughput sample management) for biologics characterization, quantitation in biological matrices, metabolite identification, and impurity profiling. Hands-on experience performing metabolic stability and metabolite ID studies using LC-MS/MS.  Sample preparation and bioanalysis of preclinical in vitro and vivo ADME/PK studies. 
• Support candidate selection by developing and driving DMPK strategies for lead optimization and solving ADME-related issues.
• Experience with Chromeleon, MassHunter, or MassLynx is a plus.
• Experience with standard conjugation chemistries is a plus. 
• Demonstrated proficiency in both hands-on analytical work and management activities.  Has experience reviewing, organizing, and presenting analytical data.
• Flexibility to work on multiple projects in a fast-paced start-up environment is essential.
• Good communication skills are essential.

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