Scientist

W2 Contract

Location: Berkeley, CA - Onsite Role

Job Summary:

We are looking for a Scientist to execute and optimize high-stakes cell culture, molecular biology, and long-read sequencing workflows. You will play a pivotal role in therapeutic screening and platform advancement. The ideal candidate is a self-starter who can translate high-level experimental goals into reproducible, robust workflows while making data-driven decisions.

Duties and Responsibilities:

• Execute and optimize cell culture and electroporation workflows, maintaining primary and engineered systems to support therapeutic screening.
• Design and run ddPCR assays as primary readouts, owning everything from primer design to data analysis of knockdown efficiency.
• Prepare high-molecular-weight DNA and intact RNA for PacBio Revio HiFi and Iso-Seq workflows.
• Execute SMRTbell library prep, including end repair, adapter ligation, and size selection for optimal Revio platform performance.
• Perform quality control using Qubit, NanoDrop, TapeStation/Femto Pulse, and fragment analysis.
• Partner with internal teams and vendors to resolve issues like low yield or suboptimal read lengths; support the transition to automated liquid-handling systems.
• Establish robust SOPs and support the scale-up of molecular assays.

Requirements and Qualifications:

• B.S. in Molecular Biology, Cell Biology, Bioengineering, or a related field (Advanced degree preferred).
• 2+ years of hands-on experience with core techniques (nucleic acid extraction, PCR/qPCR/ddPCR, cloning).
• 1+ year of experience with aseptic technique for mammalian tissue culture.
• 1+ year of experience in NGS sample prep, library preparation, and associated quality control.
• Direct experience culturing and differentiating human ES cells and/or iPS cells is required.
• Ability to work independently in a fast-paced environment and clearly communicate technical blockers and progress.

Bayside Solutions, Inc. is not able to sponsor any candidates at this time. Additionally, candidates for this position must qualify as a W2 candidate.

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