Salary range £24,589 to £30,995 pa plus excellent benefits. Fixed-term 2 years with possible extension.
The Sanger Institute Malaria Programme generates and analyses large-scale genome datasets in order to understand how parasite genetics affects the biology and epidemiology of malaria. The Sanger Malaria Programme is now looking for an Advanced Research Assistant to play a part in developing new genetic tools to manipulate Plasmodium genomes. Recent developments in our team have allowed us to scale up reverse genetic analysis of the rodent model malaria parasite Plasmodium berghei (Gomes et al. (2015) Cell Host Microbe PMID: 25732065). We are now turning our efforts towards human malaria parasites, with the focus of this role being the translation of vector production and transfection technology to human-infective species such as Plasmodium falciparum.
The person will use a combination of advanced molecular biology techniques including Gibson assembly, recombineering and Gateway technology to produce gene targeting constructs. The role will also support the team with other molecular biology tasks associated with conducting genome-wide KO screens. This is chiefly a vector pipeline / production position, where the majority of the day-to-day activities will be to perform molecular biology techniques. However, the long-term goals of the role extends to transfecting the constructs into parasites at a mid- to high- throughput scale.
- The successful applicant will have a biological sciences degree (BSc or equivalent), with previous experience working with DNA and using a range of molecular biology techniques.
- The successful candidate will have experience of mammalian cell culture work, working under sterile conditions.
- The individual will have to work closely with other members of a small team, so excellent communication and collaboration skills are essential.
- They will be able to work without constant supervision, enjoying working independently but as part of a team, with an adaptable approach to their workload.
- The candidate will have excellent organisation and record keeping skills, be methodical and technically minded.
- The individual will have basic computer skills.
- Experience in culturing Plasmodium falciparum is desirable but not essential.
The Sanger Institute is a charitably funded research centre focused on understanding the role of genetics in health and disease. We use state of the art large-scale genomic approaches to drive world-leading projects to uncover the basis of genetic and infectious disease. Our goal is to provide results that can be translated into diagnostics, treatments or therapies that reduce global health burdens.
The Institute is located near Cambridge, UK on the stunning Wellcome Genome Campus. This growing and dynamic site is the British hub of genomic science. It hosts the European Bioinformatics Institute (EBI), Open Targets, a Biodata Innovation Centre and will soon host Genomics England Limited’s 100,000 Genomes Sequencing Centre. The Campus is also home to Wellcome Genome Campus Connecting Science.
Our Benefits include: Defined Contribution Pension Scheme, Group Income Protection, Healthcare scheme, Childcare Vouchers, Workplace Nursery and 25 days Annual Leave, increasing by one day per year up to a maximum of 30, plus Bank Holidays. We also have a gym, two cafes, dining facilities, and a free campus bus service. Our thriving Sports and Social Club provides many opportunities to meet with people working across the campus.
Wellcome Trust Sanger Institute welcomes applications from all candidates irrespective of age, disability, gender, gender identity, sexual orientation, race, religion or belief, or marital or civil partnership status.
Closing date for applications: 17th March 2017 , however applications will be considered and reviewed on an on-going basis and therefore the post may be filled before the deadline.