Postdoctoral Fellow, Biotherapeutics Pharmaceutical Sciences (995018) St. Louis, Missouri

Org Marketing Statement
All over the world, Pfizer colleagues are working together to positively impact health for everyone, everywhere. Each position at Pfizer touches and contributes to the success of our business and our world. That’s why, as one of the global leaders in the biopharmaceutical industry, Pfizer is committed to seeking out inspired new talent who share our core values and mission of making the world a healthier place.

Role Description
A postdoctoral researcher is sought to conduct fundamental computational research to understand sequence—structural origins that underpin develop-ability challenges in antibody based therapeutics, especially monoclonal antibodies and antibody-drug conjugates. The research shall involve an inter-disciplinary mix of multi-scale molecular modeling and dynamics simulations, statistics, bioinformatics and high performance computing to advance our understanding of solution behavior of highly concentrated biologics. The researcher shall be expected to develop novel approaches focused at early detection of develop-ability challenged therapeutic candidates and suggest ways to improve manufacturability of biotherapeutics. Other duties as assigned time to time.

The successful candidate shall be high motivated, independent, hard working, productive and team player. He/she shall be expected to publish in high impact scientific journals and contribute towards Pfizer’s expertise on biopharmaceutical drug development.

Recent Ph.D. in Computational Molecular Biophysics or related fields

DESIRABLE: One or two years of postdoctoral research experience. Record of first class scientific research productivity as demonstrated by publications in high impact journals

Advanced understanding of antibody structure-function, protein folding-aggregation, and viscosity of highly concentrated antibody solutions. Expertise in computer programming, molecular modeling, coarse-grained and all atom MD simulations of large macromolecules.

Expertise with MOE, Discovery Studio, Schrodinger, VMD, MATLAB and modern programming languages

Fluent in oral and written English. Good inter-personal and communication skills

Equal Employment Opportunity
Pfizer is committed to equal opportunity in the terms and conditions of employment for all employees and job applicants without regard to race, color, religion, sex, sexual orientation, age, gender identity or gender expression, national origin, disability or veteran status. Pfizer also complies with all applicable national, state and local laws governing nondiscrimination in employment as well as work authorization and employment eligibility verification requirements of the Immigration and Nationality Act and IRCA. Pfizer is an E-Verify employer.

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